Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection?
Identifieur interne : 006753 ( Main/Exploration ); précédent : 006752; suivant : 006754Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection?
Auteurs : Joseph Kattan [Liban] ; Clarisse Kattan [Liban] ; Tarek Assi [Liban]Source :
- Immunotherapy [ 1750-743X ] ; ????.
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. Immune checkpoint inhibitors have largely impacted the prognosis of a multitude of malignancies with significant improvement in survival outcomes and a different, tolerable toxicity profile. In this paper, we assess the safety of ICI administration in cancer patients during the coronavirus pandemic in order to guide the usage of these highly efficacious agents.
Url:
DOI: 10.2217/imt-2020-0077
PubMed: 32290754
PubMed Central: 7161588
Affiliations:
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compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection?</title><author><name sortKey="Kattan, Joseph" sort="Kattan, Joseph" uniqKey="Kattan J" first="Joseph" last="Kattan">Joseph Kattan</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Kattan, Clarisse" sort="Kattan, Clarisse" uniqKey="Kattan C" first="Clarisse" last="Kattan">Clarisse Kattan</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Assi, Tarek" sort="Assi, Tarek" uniqKey="Assi T" first="Tarek" last="Assi">Tarek Assi</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author></analytic><series><title level="j">Immunotherapy</title><idno type="ISSN">1750-743X</idno><idno type="eISSN">1750-7448</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. Immune checkpoint inhibitors have largely impacted the prognosis of a multitude of malignancies with significant improvement in survival outcomes and a different, tolerable toxicity profile. In this paper, we assess the safety of ICI administration in cancer patients during the coronavirus pandemic in order to guide the usage of these highly efficacious agents.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Del Rio, C" uniqKey="Del Rio C">C del Rio</name></author><author><name sortKey="Malani, Pn" uniqKey="Malani P">PN Malani</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Remuzzi, A" uniqKey="Remuzzi A">A Remuzzi</name></author><author><name sortKey="Remuzzi, G" uniqKey="Remuzzi G">G Remuzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL 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uniqKey="Romero F">FA Romero</name></author><author><name sortKey="Arguello, E" uniqKey="Arguello E">E Argüello</name></author><author><name sortKey="Kyi, C" uniqKey="Kyi C">C Kyi</name></author><author><name sortKey="Postow, Ma" uniqKey="Postow M">MA Postow</name></author><author><name sortKey="Redelman Sidi, G" uniqKey="Redelman Sidi G">G Redelman-Sidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assi, T" uniqKey="Assi T">T Assi</name></author><author><name sortKey="Danu, A" uniqKey="Danu A">A Danu</name></author><author><name sortKey="Mateus, C" uniqKey="Mateus C">C Mateus</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Liban</li></country></list><tree><country name="Liban"><noRegion><name sortKey="Kattan, Joseph" sort="Kattan, Joseph" uniqKey="Kattan J" first="Joseph" last="Kattan">Joseph Kattan</name></noRegion><name sortKey="Assi, Tarek" sort="Assi, Tarek" uniqKey="Assi T" first="Tarek" last="Assi">Tarek Assi</name><name sortKey="Kattan, Clarisse" sort="Kattan, Clarisse" uniqKey="Kattan C" first="Clarisse" last="Kattan">Clarisse Kattan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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